Pakistan is in the middle of epidemiological transition where about 60% of total disease burden is due to infectious or communicable diseases. Health characteristics of Balochistan are a typical example of the national situation with low life expectancy, widespread communicable diseases, and high child and maternal mortality rate.However, Balochistan has a reasonable health infrastructure. The problem mainly lies in their utilization and management. PPHI Balochistan is mandated to manage the basic health infrastructure effectively and enhance their utilization. PPHI’s annual health report 2018 showed that 60 % Burden of diseases recorded at BHUs were communicable diseases.The main communicable diseases that account for disease burden were respiratory infections (22%), diarrheal diseases (18%), suspected malaria (4.2%), fever due to other causes (12%) urinary tract infections and sexually transmitted infections (3.2%), scabies/skin infections (3.4%) and the childhood cluster of vaccine preventable diseases (infant TB, pneumonia, measles, pertussis, poliomyelitis, diphtheria, meningitis, tetanus; (0.3 %). Diarrheal diseases, respiratory infections, and the childhood cluster of vaccine preventable diseases mostly affect under five years’ children were (7%). Tuberculosis affects both children and adults. PPHI-B employs a proactive strategy on disease control. On one hand, it treats the existing medical conditions. On the other, it pre-empts the onset of diseases by health education through its social organizers and health staffs. For the prevention of many disabling and fatal diseases, PPHI offers vaccination services in a sustained manner. PPHI health staff examines every child that visits a BHU to find out whether they have been fully immunized against the vaccine-preventable illnesses.